Overlap Syndromes of Myeloid Neoplasms: Pathobiology, Diagnosis, and Therapeutic Implications
Marsela Shani
ABSTRACT
Myeloid neoplasms encompass a spectrum of clonal hematopoietic stem cell disorders characterized by dysregulated proliferation and differentiation. Among these, overlap syndromes particularly myelodysplastic/myeloproliferative neoplasms (MDS/MPN) represent a biologically and clinically heterogeneous group that straddles the boundaries between myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN). Advances in molecular profiling have refined diagnostic criteria and revealed shared pathogenic mechanisms that unify and distinguish these entities. This review summarizes recent insights into the molecular landscape, diagnostic challenges, and evolving therapeutic approaches to MDS/MPN overlap syndromes.
